ABSTRACTInteraction between nutraceuticals and antibiotics has attracted increasing interest as a potential approach to improve antibiotic efficacy. This scoping review aims to provide a comprehensive overview of the existing literature on the effects of nutraceuticals on antibiotic efficacy. An information specialist executed a multi-database search following the PRISMA-2020 guidelines to find articles published between 1 January 2013, and 1 April 2023. The addition of nutraceuticals to antibiotic treatments has shown promising results, for urinary tract infections, the supplementation of vitamin E alongside antibiotics significantly reduced the frequency of fever and urinary symptoms. In patients with hidradenitis suppurativa, the combination of MI, folic acid, and liposomal magnesium improved the efficacy of concurrent therapies and metabolic profiles. Immune manipulation with a nutraceutical alongside antibiotics proved effective and safe in reducing symptoms over time. These findings highlight the potential of nutraceutical addition to antibiotics in improving patient outcomes.