Antibiotic resistance is increasing in the biosphere, but the antibiotic resistome in the plant microbiome is overlooked compared to its presence in soil and water environments. The plant microbiome can act as the interface between human and natural microbiomes, representing a crucial pathway for human exposure to environmental antibiotic resistance. Microorganisms associated with plants may exacerbate the dissemination of antibiotic resistance via the food chain, direct contact, and globalization. Microorganisms associated with plants may alter the traits of the human microbiome important for human health, but this alteration has largely been overlooked. The plant microbiome is an interface between plants and the environment, and provides many ecosystem functions such as improving nutrient uptake and protecting against biotic and abiotic stress. The plant microbiome also represents a major pathway by which humans are exposed to microbes and genes consumed with food, such as pathogenic bacteria, antibiotic-resistant bacteria, and antibiotic-resistance genes. In this review we highlight the main findings on the composition and function of the plant microbiome, and underline the potential of plant microbiomes in the dissemination of antibiotic resistance via food consumption or direct contact.