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  • Expression Of The Bcl2 Gene...
    Vucicevic, Ksenija; Jakovljevic, Vladimir; Sretenovic, Jasmina; Tosic, Natasa; Kostic, Tatjana; Glumac, Irena; Colovic, Milica; Colovic, Natasa; Pavlovic, Sonja; Karan-Djurasevic, Teodora

    Serbian Journal of Experimental and Clinical Research, 9/2015, Letnik: 16, Številka: 3
    Journal Article

    Chronic lymphocytic leukaemia (CLL) manifests as clonal expansion of mature B lymphocytes, whose accumulation is primarily attributed to the dysregulation of apoptosis. Aberrant expression, as well as genetic alterations within various Bcl2 family members and central regulators of the intrinsic, mitochondria-mediated apoptotic pathway all hasve been observed in CLL. Here, we report the expression analysis of the anti-apoptotic Bcl2 gene in a cohort of 58 CLL patients. Quantitative reverse-transcriptase polymerase chain reaction (qRT-PCR) analysis revealed a significant overexpression of Bcl2 mRNA in CLL samples compared to control samples (p=<0.001). Receiver operating characteristic (ROC) analysis showed that the level of Bcl2 expression exerts a high discriminatory power between patients and healthy subjects (A=0.98, 95% CI=0.95-1.009, p<0.0001).