Display omitted •A general gas–solid turbulence model is validated for different flow regimes.•Model parameters can be determined through a dynamic adjustment procedure.•Meso-scale production of variances in the solids volume fraction due to clustering.•Wall boundary conditions for the turbulent kinetic energy are derived.•Dynamic adjustment procedure yields grid-size independent results. The Spatially-Averaged Two-Fluid Model (SA-TFM) is a functional multiphase turbulence model aimed at predicting the influence of unresolved meso-scale structures on the macro-scale flow properties in coarse-grid simulations of gas-particle flows. In this study, we highlight the general applicability of the SA-TFM model due to the dynamic estimation of the model coefficients through test-filters, the anisotropic treatment of the Reynolds-stresses and the drag force correction, and additional wall-friction boundary conditions for the particle-phase velocity, Reynolds-stress and turbulent kinetic energy. The dynamic approach derives information on the unresolved meso-scale flow properties from the resolved macro-scale variables without the need for any intensive prior considerations of the specific flow structure. Thereby, the drift velocity, a measure for the drag-reduction due to the presence of meso-scale structures is estimated from the turbulent kinetic energies of the phases and the variance of the solids volume fraction. We validate the dynamic anisotropic SA-TFM against highly resolved fine-grid Two-Fluid Model simulation data and experimental measurements of Geldart type A and B particles in bubbling to turbulent flow regimes. In the course of this extensive study, we find that the predictions for the macro-scale flow properties, such as slip-velocity, bed expansion, volume fraction distribution, and mass-flux, are in good agreement with the experimental and fine-grid simulation data in a vast number of cases, ranging from unbound fluidization to pilot-scale fluidized beds, thus, implying a wide applicability of the dynamic model independent of the underlying grid-size.