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Jia, Tao; Smith, Marshall J; Pulis, Alexander P; Perry, Gregory J. P; Procter, David J
ACS catalysis, 08/2019, Letnik: 9, Številka: 8Journal Article
A multicomponent copper-catalyzed enantio- and regioselective borocyanation of 1-aryl-1,3-butadienes has been developed. The method provides access to functionalized allylic nitriles in up to 90% yield and 94% ee and thus overcomes some of the long-standing problems associated with the enantioselective insertion of cyano groups into unsaturated organic molecules. Both boron and cyano functionalities can be used as handles for selective manipulation.
