E-viri
PDF
Recenzirano
Odprti dostop
-
Lin, Richard J.; Afshar-Kharghan, Vahid; Schafer, Andrew I.
Blood, 07/2014, Letnik: 124, Številka: 2Journal Article
Paraneoplastic thrombocytosis is associated with many solid tumors and often correlates with reduced survival. Recent studies suggest that a pathogenic feed back loop may be operative between platelets and tumor cells, with reciprocal interactions between tumor growth/metastasis and thrombocytosis/platelet activation. Specific molecular pathways have been identified in which tumors can stimulate platelet production and activation; activated platelets can, in turn, promote tumor growth and metastasis. Taken together, these findings provide exciting new potential targets for therapeutic intervention.
