E-viri
Recenzirano
Odprti dostop
-
Alghamdi, Abeer; Birch, David J.S.; Vyshemirsky, Vladislav; Rolinski, Olaf J.
The journal of physical chemistry. B, 09/2022, Letnik: 126, Številka: 38Journal Article
We report the effects of quercetin, a flavonoid present in the human diet, on early stage beta-amyloid (Aβ) aggregation, a seminal event in Alzheimer’s disease. Molecular level changes in Aβ arrangements are monitored by time-resolved emission spectral (TRES) measurements of the fluorescence of Aβ’s single tyrosine intrinsic fluorophore (Tyr). The results suggest that quercetin binds β-amyloid oligomers at early stages of their aggregation, which leads to the formation of modified oligomers and hinders the creation of β-sheet structures, potentially preventing the onset of Alzheimer’s disease.
