E-viri
PDF
Recenzirano
Odprti dostop
-
Yang, Kevin; Pulis, Alexander P; Perry, Gregory J. P; Procter, David J
Organic letters, 12/2018, Letnik: 20, Številka: 23Journal Article
We report a transition-metal-free synthesis of benzofurans from benzothiophenes and phenols that exploits the unique reactivity of sulfoxides. Through a sequence involving an interrupted Pummerer reaction and 3,3 sigmatropic rearrangement, phenols can be combined with readily accessible yet synthetically unexplored benzothiophene S-oxides to provide C3-arylated benzofuran products. The products from this approach can undergo subsequent functionalization to gain access to a range of important benzofuran derivatives.
