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Ozaki, Tomoya; Yorimitsu, Hideki; Perry, Gregory J.P.
Tetrahedron, 07/2022, Letnik: 117-118Journal Article
Sulfonamides are present in a range of useful molecules, such as drugs and agrochemicals. In recent years, the functionalization of sulfonamides via S–N bond cleavage has received increased attention. In this report, we detail an accessible and low-cost route for transforming primary sulfonamides into the corresponding sulfonic acids/sulfonates via sulfonyl pyrroles. The reaction is demonstrated with a range of substrates including aryl and alkyl sulfonamides, and in the late-stage functionalization of several sulfonamide-containing drug molecules. To create your abstract, type over the instructions in the template box below. Fonts or abstract dimensions should not be changed or altered. Display omitted
