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Barker, Brianne R; Parvani, Jenny G; Meyer, Debra; Hey, Adam S; Skak, Kresten; Letvin, Norman L
The Journal of immunology (1950), 09/2007, Letnik: 179, Številka: 6Journal Article
IL-21, a member of the common gamma-chain family of cytokines, has pleiotropic effects on T, B, and NK cells. We found that IL-21 and the prototype common gamma-chain cytokine IL-2 can stimulate proliferation and cytokine secretion by Ag-specific rhesus monkey CD8+ T cells. However, unique among the members of this family of cytokines, we found that IL-21 drives these cells to apoptosis by down-regulation of Bcl-2. These findings suggest that IL-21 may play an important role in the contraction of CD8+ T cell responses.
