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Moscat, Jorge; Karin, Michael; Diaz-Meco, Maria T.
Cell, 10/2016, Letnik: 167, Številka: 3Journal Article
Adaptor proteins participate in selective autophagy, which is critical for cellular detoxification and stress relief. However, new evidence supports an autophagy-independent key role of the adaptor p62 (encoded by the gene Sqstm1) in signaling functions central to tumor initiation in the epithelium and suppression of tumor progression in the stroma. New evidence supports an autophagy-independent key role of the adaptor p62 in cancer.
