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Weberling, Antonia; Zernicka-Goetz, Magdalena
Cell reports (Cambridge), 01/2021, Letnik: 34, Številka: 3Journal Article
Implantation is a hallmark of mammalian embryogenesis during which embryos establish their contacts with the maternal endometrium, remodel, and undertake growth and differentiation. The mechanisms and sequence of events through which embryos change their shape during this transition are largely unexplored. Here, we show that the first extraembryonic lineage, the polar trophectoderm, is the key regulator for remodeling the embryonic epiblast. Loss of its function after immuno-surgery or inhibitor treatments prevents the epiblast shape transitions. In the mouse, the polar trophectoderm exerts physical force upon the epiblast, causing it to transform from an oval into a cup shape. In human embryos, the polar trophectoderm behaves in the opposite manner, exerting a stretching force. By mimicking this stretching behavior in mouse embryogenesis, we could direct the epiblast to adopt the disc-like shape characteristic of human embryos at this stage. Thus, the polar trophectoderm acts as a conserved regulator of epiblast shape. Display omitted •Mouse epiblast remodeling from blastocyst to egg cylinder is achieved in five stages•Epiblast remodeling upon implantation is not inherent to the embryonic lineage•The polar trophectoderm mediates epiblast shape acquisition•Epiblast shape regulation by the polar trophectoderm appears conserved in evolution Weberling and Zernicka-Goetz characterize the remodeling of the mouse epiblast upon implantation. Its transformation from oval to cup shaped is driven by the polar trophectoderm tissue. Comparative analyses with human embryos and inhibitor treatments suggest the polar trophectoderm as an evolutionarily conserved regulator of epiblast shape upon implantation.
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