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Ashtari, Fereshteh; Bahar, Mohammadali; Aghaei, Maryam; Zahed, Arash
Journal of clinical neuroscience, 05/2013, Letnik: 20, Številka: 5Journal Article
Abstract Uric acid (UA) is a hydrophilic antioxidant product associated with multiple sclerosis (MS). We conducted a randomized case-control study to evaluate the serum level of UA in different phases of MS in comparison with levels in a healthy control population. Serum UA was checked in 130 patients with relapsing-remitting MS (85 patients in remitting and 45 patients in relapsing phase) and 50 age-matched controls using a quantitative enzyme-linked immunosorbent assay (ELISA). The mean concentrations of UA in serum was 6.41(±3.18) mg/dL in patients with remitting MS, 4.76(±1.66) mg/dL in patients with relapsing MS and 6.33(±2.94) mg/dL in controls. There was a significant difference between mean UA concentration in relapsing MS and remitting MS ( p < 0.001), and between patients with relapsing MS and controls ( p = 0.002); however, the difference between levels for patients in the remitting phase of MS and the control group was not significant ( p = 0.87). It seems probable that UA has a role in the prevention of disease activity in MS.
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Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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