E-viri
Recenzirano
Odprti dostop
-
Andrews, Miles C; Oba, Junna; Wu, Chang-Jiun; Zhu, Haifeng; Karpinets, Tatiana; Creasy, Caitlin A; Forget, Marie-Andrée; Yu, Xiaoxing; Song, Xingzhi; Mao, Xizeng; Robertson, A Gordon; Romano, Gabriele; Li, Peng; Burton, Elizabeth M; Lu, Yiling; Sloane, Robert Szczepaniak; Wani, Khalida M; Rai, Kunal; Lazar, Alexander J; Haydu, Lauren E; Bustos, Matias A; Shen, Jianjun; Chen, Yueping; Morgan, Margaret B; Wargo, Jennifer A; Kwong, Lawrence N; Haymaker, Cara L; Grimm, Elizabeth A; Hwu, Patrick; Hoon, Dave S B; Zhang, Jianhua; Gershenwald, Jeffrey E; Davies, Michael A; Futreal, P Andrew; Bernatchez, Chantale; Woodman, Scott E
Nature communications, 07/2022, Letnik: 13, Številka: 1Journal Article
Melanoma cells display distinct intrinsic phenotypic states. Here, we seek to characterize the molecular regulation of these states using multi-omic analyses of whole exome, transcriptome, microRNA, long non-coding RNA and DNA methylation data together with reverse-phase protein array data on a panel of 68 highly annotated early passage melanoma cell lines. We demonstrate that clearly defined cancer cell intrinsic transcriptomic programs are maintained in melanoma cells ex vivo and remain highly conserved within melanoma tumors, are associated with distinct immune features within tumors, and differentially correlate with checkpoint inhibitor and adoptive T cell therapy efficacy. Through integrative analyses we demonstrate highly complex multi-omic regulation of melanoma cell intrinsic programs that provide key insights into the molecular maintenance of phenotypic states. These findings have implications for cancer biology and the identification of new therapeutic strategies. Further, these deeply characterized cell lines will serve as an invaluable resource for future research in the field.
Avtor
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.