The current research was directed to explore hybrid vigour for hybrids resulting from crosses among six genotypes of the genus Citrullus, including C. mucosospermus. For such purpose, the mid parent heterosis and the best parent heterosis were assessed. Non parametric method related to homogeneity Chi-square at 5 % likelihood was applied to compare the regeneration potential of progenies. Student's parametric test at 5% was used to separe two means. Six parental genotypes and 16 hybrid families were evaluated for heterosis. The results showed a heterosis effect for all the characters studied nevertheless, this one varies according to the crossing. The observed hybrid vigour would be due to a superdominance or partial dominance effect. In addition, progeny from crosses have the same regenerative potential on both study sites. Genetic improvement; Progenies from crosses; Student's Z test; Hybrid vigour; Heterosis; Citrullus mucosospermus; Agronomy; Biological sciences; Plant biology; Biotechnology; Genetics.