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Zuklys, Saulius; Mayer, Carlos E; Zhanybekova, Saule; Stefanski, Heather E; Nusspaumer, Gretel; Gill, Jason; Barthlott, Thomas; Chappaz, Stephane; Nitta, Takeshi; Dooley, James; Nogales-Cadenas, Ruben; Takahama, Yousuke; Finke, Daniela; Liston, Adrian; Blazar, Bruce R; Pascual-Montano, Alberto; Holländer, Georg A
The Journal of immunology (1950), 2012-Oct-15, 2012-10-15, 20121015, Letnik: 189, Številka: 8Journal Article
Thymic epithelial cells provide unique cues for the lifelong selection and differentiation of a repertoire of functionally diverse T cells. Rendered microRNA (miRNA) deficient, these stromal cells in the mouse lose their capacity to instruct the commitment of hematopoietic precursors to a T cell fate, to effect thymocyte positive selection, and to achieve promiscuous gene expression required for central tolerance induction. Over time, the microenvironment created by miRNA-deficient thymic epithelia assumes the cellular composition and structure of peripheral lymphoid tissue, where thympoiesis fails to be supported. These findings emphasize a global role for miRNA in the maintenance and function of the thymic epithelial cell scaffold and establish a novel mechanism how these cells control peripheral tissue Ag expression to prompt central immunological tolerance.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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