Salt tolerance is an important constrain for rice, which is generally categorized as a typicalglycophyte. Soil salinity is one of the major constraints affecting rice production worldwide, especially inthe coastal areas. Susceptibility or tolerance of rice plants to high salinity is a coordinated action ofmultiple stress responsive genes, which also interacts with other components of stress signaltransduction pathways. Salt tolerant varieties can be produced by marker-assisted selection or geneticengineering by introducing salt-tolerance genes. In this review, we have updated on mechanisms andgenes which can help in transferring of the salt tolerance into high-yielding rice varieties. We havefocused on the need for integrating phenotyping, genomics, metabolic profiling and phenomics intotransgenic and breeding approaches to develop high-yielding as well as salt tolerant rice varieties.