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Xu, Ling; Pegu, Amarendra; Rao, Ercole; Doria-Rose, Nicole; Beninga, Jochen; McKee, Krisha; Lord, Dana M.; Wei, Ronnie R.; Deng, Gejing; Louder, Mark; Schmidt, Stephen D.; Mankoff, Zachary; Wu, Lan; Asokan, Mangaiarkarasi; Beil, Christian; Lange, Christian; Leuschner, Wulf Dirk; Kruip, Jochen; Sendak, Rebecca; Kwon, Young Do; Zhou, Tongqing; Chen, Xuejun; Bailer, Robert T.; Wang, Keyun; Choe, Misook; Tartaglia, Lawrence J.; Barouch, Dan H.; O’Dell, Sijy; Todd, John-Paul; Burton, Dennis R.; Roederer, Mario; Connors, Mark; Koup, Richard A.; Kwong, Peter D.; Yang, Zhi-yong; Mascola, John R.; Nabel, Gary J.
Science, 10/2017, Letnik: 358, Številka: 6359Journal Article
The development of an effective AIDS vaccine has been challenging because of viral genetic diversity and the difficulty of generating broadly neutralizing antibodies (bnAbs). We engineered trispecific antibodies (Abs) that allow a single molecule to interact with three independent HIV-1 envelope determinants: the CD4 binding site, the membrane-proximal external region (MPER), and the V1V2 glycan site. Trispecific Abs exhibited higher potency and breadth than any previously described single bnAb, showed pharmacokinetics similar to those of human bnAbs, and conferred complete immunity against a mixture of simian-human immunodeficiency viruses (SHIVs) in nonhuman primates, in contrast to single bnAbs. Trispecific Abs thus constitute a platform to engage multiple therapeutic targets through a single protein, and they may be applicable for treatment of diverse diseases, including infections, cancer, and autoimmunity.
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Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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