Abstract The nearby, luminous infrared galaxy NGC 7469 hosts a Seyfert nucleus with a circumnuclear star-forming ring and is thus the ideal local laboratory for investigating the starburst–AGN (active galactic nucleus) connection in detail. We present integral-field observations of the central 1.3 kpc region in NGC 7469 obtained with the JWST Mid-InfraRed Instrument. Molecular and ionized gas distributions and kinematics at a resolution of ∼100 pc over the 4.9–7.6 μ m region are examined to study the gas dynamics influenced by the central AGN. The low-ionization Fe ii λ 5.34 μ m and Ar ii λ 6.99 μ m lines are bright on the nucleus and in the starburst ring, as opposed to H 2 S(5) λ 6.91 μ m, which is strongly peaked at the center and surrounding ISM. The high-ionization Mg v line is resolved and shows a broad, blueshifted component associated with the outflow. It has a nearly face-on geometry that is strongly peaked on the nucleus, where it reaches a maximum velocity of −650 km s −1 , and extends about 400 pc to the east. Regions of enhanced velocity dispersion in H 2 and Fe ii ∼ 180 pc from the AGN that also show high L (H 2 )/ L (PAH) and L (Fe ii )/ L (Pf α ) ratios to the W and N of the nucleus pinpoint regions where the ionized outflow is depositing energy, via shocks, into the dense interstellar medium between the nucleus and the starburst ring. These resolved mid-infrared observations of the nuclear gas dynamics demonstrate the power of JWST and its high-sensitivity integral-field spectroscopic capability to resolve feedback processes around supermassive black holes in the dusty cores of nearby luminous infrared galaxies.