E-viri
PDF
Recenzirano
Odprti dostop
-
Kim, Jaegil; Bellmunt, Joaquim; Cherniack, Andrew D.; Hinoue, Toshinori; Hoadley, Katherine A.; Gibb, Ewan A.; Shukla, Sachet A.; Sanchez-Vega, Francisco; Reuter, Victor E.; Sadeghi, Sara; Pedamallu, Chandra Sekhar; Lu, Yiling; Klimczak, Leszek J.; Zhang, Jiexin; Choo, Caleb; Leraas, Kristen M.; Lichtenberg, Tara M.; Schultz, Nicholaus; Getz, Gad; Mills, Gordon B.; Al-Ahmadie, Hikmat; Alexopoulou, Iakovina; Ally, Adrian; Beaver, Allison; Bellmunt, Joaquim; Boice, Lori; Bootwalla, Moiz S.; Bowen, Jay; Brooks, Denise; Broom, Bradley M.; Bshara, Wiam; Bullman, Susan; Burks, Eric; Carvalho, Benilton S.; Carvalho, Andre L.; Castro, Mauro A.A.; Chagas, Vinicius S.; Cherniack, Andrew D.; Cortessis, Victoria K.; Czerniak, Bogdan A.; Daneshmand, Siamak; Dhalla, Noreen; Egea, Sophie C.; Engel, Jay; Felau, Ina; Gastier-Foster, Julie M.; Getz, Gad; Gordenin, Dmitry A.; Hansel, Donna E.; Harr, Jodi; Hartmann, Arndt; Hinoue, Toshinori; Jones, Steven J.M.; Kahnoski, Richard J.; Kasaian, Katayoon; Lai, Phillip H.; Lane, Brian R.; Liu, Jia; Lolla, Laxmi; Lotan, Yair; Lu, Yiling; Lucchesi, Fabiano R.; Mallery, David; Marra, Marco A.; Mills, Gordon B.; Mungall, Karen L.; Ojesina, Akinyemi I.; Parekh, Dipen J.; Sekhar Pedamallu, Chandra; Pihl, Todd; Rathmell, W. Kimryn; Robertson, A. Gordon; Sadeghi, Sara; Saller, Charles; Salner, Andrew; Sanchez-Vega, Francisco; Scapulatempo-Neto, Cristovam; Schuckman, Anne K.; Shukla, Sachet A.; Simko, Jeff; Sipahimalani, Payal; Sorcini, Andrea; Stoehr, Robert; Su, Xiaoping; Tarnuzzer, Roy; Thiessen, Nina; Thorne, Leigh; Tse, Kane; Wach, Sven; Wang, Zhining; Weinstein, John N.; Wise, Lisa; Wong, Tina; Wu, Ye; Zach, Leigh Anne; Zenklusen, Jean C.; Zhang, Jiashan (Julia); Zhang, Jiexin; Zwarthoff, Ellen C.; Weinstein, John N.
Cell, 10/2017, Letnik: 171, Številka: 3Journal Article
We report a comprehensive analysis of 412 muscle-invasive bladder cancers characterized by multiple TCGA analytical platforms. Fifty-eight genes were significantly mutated, and the overall mutational load was associated with APOBEC-signature mutagenesis. Clustering by mutation signature identified a high-mutation subset with 75% 5-year survival. mRNA expression clustering refined prior clustering analyses and identified a poor-survival “neuronal” subtype in which the majority of tumors lacked small cell or neuroendocrine histology. Clustering by mRNA, long non-coding RNA (lncRNA), and miRNA expression converged to identify subsets with differential epithelial-mesenchymal transition status, carcinoma in situ scores, histologic features, and survival. Our analyses identified 5 expression subtypes that may stratify response to different treatments. Display omitted •Multiplatform analysis informs muscle-invasive bladder cancer subtyping•A framework associating distinct subtyping with therapeutic options•High mutational load is driven mainly by APOBEC-mediated mutagenesis•APOBEC-related mutational signature corresponds to a 75% 5-year survival A multiplatform analysis of 412 muscle-invasive bladder cancer patients provides insights into mutational profiles with prognostic value and establishes a framework associating distinct tumor subtypes with clinical options.
