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  • Subarachnoid Hemorrhage Man...
    Rajajee, Venkatakrishna; Human, Theresa

    Neurocritical care, 08/2023, Letnik: 39, Številka: 1
    Journal Article

    Given the society’s shift toward use of the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) framework of guideline development 2, 3, the scope was limited by design, with a focus on 12 management questions thought to be most impacted by new evidence and evolving management paradigms in the intervening decade. The rigor of the GRADE methodology is achieved using the following process 3: individual studies are evaluated for risk of bias 4, whereas the quality of the body of evidence for each question is evaluated within the major GRADE domains, which are risk of bias, inconsistency, indirectness, imprecision, publication bias, and factors that can increase the quality of evidence, such as a large magnitude of effect or a dose–response gradient 5. ...the panel focused on clinical outcomes including functional outcome, mortality, the occurrence of delayed cerebral ischemia, and complications of therapy rather than surrogate physiologic outcomes. ...GRADE requires the consideration of the potential risks of therapeutic interventions, such as cardiac arrhythmias and pulmonary edema, as well as the potential benefits. Conflict of interest Neither of the authors have any conflicts of interest to declare.