Abstract Proton exchange membrane water electrolysis is a promising technology to produce green hydrogen from renewables, as it can efficiently achieve high current densities. Lowering iridium amount in oxygen evolution reaction electrocatalysts is critical for achieving cost-effective production of green hydrogen. In this work, we develop catalysts from Ir double perovskites. Sr 2 CaIrO 6 achieves 10 mA cm −2 at only 1.48 V. The surface of the perovskite reconstructs when immersed in an acidic electrolyte and during the first catalytic cycles, resulting in a stable surface conformed by short-range order edge-sharing IrO 6 octahedra arranged in an open structure responsible for the high performance. A proton exchange membrane water electrolysis cell is developed with Sr 2 CaIrO 6 as anode and low Ir loading (0.4 mg Ir cm −2 ). The cell achieves 2.40 V at 6 A cm −2 (overload) and no loss in performance at a constant 2 A cm −2 (nominal load). Thus, reducing Ir use without compromising efficiency and lifetime.