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Ziegler, David S; Wong, Marie; Mayoh, Chelsea; Kumar, Amit; Tsoli, Maria; Mould, Emily; Tyrrell, Vanessa; Khuong-Quang, Dong-Anh; Pinese, Mark; Gayevskiy, Velimir; Cohn, Richard J; Lau, Loretta M S; Reynolds, Mark; Cox, Michael C; Gifford, Andrew; Rodriguez, Michael; Cowley, Mark J; Ekert, Paul G; Marshall, Glenn M; Haber, Michelle
British journal of cancer, 09/2018, Letnik: 119, Številka: 6Journal Article
Genes encoding TRK are oncogenic drivers in multiple tumour types including infantile fibrosarcoma, papillary thyroid cancer and high-grade gliomas (HGG). TRK fusions have a critical role in tumourigenesis in 40% of infant HGG. Here we report the first case of a TRK fusion-driven HGG treated with larotrectinib-the first selective pan-TRK inhibitor in clinical development. This 3-year-old girl had failed multiple therapies including chemotherapy and radiotherapy. Tumour profiling confirmed an ETV6-NTRK3 fusion. Treatment with larotrectinib led to rapid clinical improvement with near total resolution of primary and metastatic lesions on MRI imaging. This is the first report of a TRK fusion glioma successfully treated with a TRK inhibitor.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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