General Considerations...e70 Risk Assessment Using Clinical Parameters...e71 Advanced Testing: Resting and Stress Noninvasive Testing...e72 Resting Imaging to Assess Cardiac Structure and Function: Recommendations...e72 Stress Testing and Advanced Imaging in Patients With Known SIHD Who Require Noninvasive Testing for Risk Assessment: Recommendations...e74 Risk Assessment in Patients Able to Exercise...e74 Risk Assessment in Patients Unable to Exercise...e74 Risk Assessment Regardless of Patients' Ability to Exercise...e74 Exercise ECG...e75 Exercise Echocardiography and Exercise Nuclear MPI...e76 Dobutamine Stress Echocardiography and Pharmacological Stress Nuclear MPI...e77 Pharmacological Stress CMR Imaging...e77 Special Patient Group: Risk Assessment in Patients Who Have an Uninterpretable ECG Because of LBBB or Ventricular Pacing...e77 Prognostic Accuracy of Anatomic Testing to Assess Risk in Patients With Known CAD...e78 Coronary CT Angiography...e78 Coronary Angiography...e78 Coronary Angiography as an Initial Testing Strategy to Assess Risk: Recommendations...e78 Coronary Angiography to Assess Risk After Initial Workup With Noninvasive Testing: Recommendations...e78 Treatment...e80 Definition of Successful Treatment...e80 General Approach to Therapy...e82 Factors That Should Not Influence Treatment Decisions...e83 Assessing Patients' Quality of Life...e84 Patient Education: Recommendations...e84 Guideline-Directed Medical Therapy...e86 Risk Factor Modification: Recommendations...e86 Lipid Management...e86 Blood Pressure Management...e88 Diabetes Management...e89 Physical Activity...e91 Weight Management...e92 Smoking Cessation Counseling...e92 Management of Psychological Factors...e93 Alcohol Consumption...e94 Avoiding Exposure to Air Pollution...e94 Additional Medical Therapy to Prevent MI and Death: Recommendations...e95 Antiplatelet Therapy...e95 Beta-Blocker Therapy...e96 Renin-Angiotensin-Aldosterone Blocker Therapy...e97 Influenza Vaccination...e98 Additional Therapy to Reduce Risk of MI and Death...e99 Medical Therapy for Relief of Symptoms...e100 Use of Anti-ischemic Medications: Recommendations...e100 Alternative Therapies for Relief of Symptoms in Patients With Refractory Angina: Recommendations...e104 Enhanced External Counterpulsation...e104 Spinal Cord Stimulation...e105 Acupuncture...e105 CAD Revascularization...e106 Heart Team Approach to Revascularization Decisions: Recommendations...e106 Revascularization to Improve Survival: Recommendations...e108 Revascularization to Improve Symptoms: Recommendations...e109 CABG Versus Contemporaneous Medical Therapy...e109 PCI Versus Medical Therapy...e110 CABG Versus PCI...e110 CABG Versus Balloon Angioplasty or BMS...e110 CABG Versus DES...e111 Left Main CAD...e111 CABG or PCI Versus Medical Therapy for Left Main CAD...e111 Studies Comparing PCI Versus CABG for Left Main CAD...e111 Revascularization Considerations for Left Main CAD...e112 Proximal LAD Artery Disease...e112 Clinical Factors That May Influence the Choice of Revascularization...e113 Completeness of Revascularization...e113 LV Systolic Dysfunction...e113 Previous CABG...e113 Unstable Angina/Non-ST-Elevation Myocardial Infarction...e113 DAPT Compliance and Stent Thrombosis: Recommendation...e113 Transmyocardial Revascularization...e114 Hybrid Coronary Revascularization: Recommendations...e114 Special Considerations...e114 Women...e115 Older Adults...e115 Diabetes Mellitus...e116 Obesity...e117 Chronic Kidney Disease...e118 HIV Infection and SIHD...e118 Autoimmune Disorders...e119 Socioeconomic Factors...e119 Special Occupations...e119 Patient Follow-Up: Monitoring of Symptoms and Antianginal Therapy...e119 Clinical Evaluation, Echocardiography During Routine, Periodic Follow-Up: Recommendations...e120 Follow-Up of Patients With SIHD...e121 Focused Follow-Up Visit: Frequency...e121 Focused Follow-Up Visit: Interval History and Coexisting Conditions...e121 Focused Follow-Up Visit: Physical Examination...e122 Focused Follow-Up Visit: Resting 12-Lead ECG...e122 Focused Follow-Up Visit: Laboratory Examination...e122 Noninvasive Testing in Known SIHD...e122 Follow-Up Noninvasive Testing in Patients With Known SIHD: