E-viri
Recenzirano
Odprti dostop
-
Cai, Xinpei; Li, Lei; Wang, Ye-Cheng; Zhou, Jianhan; Dai, Mingji
Organic letters, 07/2023, Letnik: 25, Številka: 28Journal Article
Herein, we report the total syntheses of phleghenrines A and C from commercially available starting materials in 7 and 8 steps, respectively. Notable steps include an inverse electron-demand Diels–Alder reaction between a masked o-benzoquinone and a N-protected enamine to prepare one key intermediate with a bicyclo2.2.2octenone core, a Büchner–Curtius–Schlotterbeck one-carbon insertion to expand the bicyclo2.2.2octenone to a bicyclo3.2.2nonenone, and Trauner’s modified 2-pyridone synthesis to install the 2-pyridone moiety.
