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Zhang, Shengbo; Rautela, Jai; Bediaga, Naiara G; Kolesnik, Tatiana B; You, Yue; Nie, Junli; Dagley, Laura F; Bedo, Justin; Wang, Hanqing; Sun, Li; Sutherland, Robyn; Surgenor, Elliot; Iannarella, Nadia; Allan, Rhys; Souza-Fonseca-Guimaraes, Fernando; Xie, Yi; Wang, Qike; Zhang, Yuxia; Xu, Yuekang; Nutt, Stephen L; Lew, Andrew M; Huntington, Nicholas D; Nicholson, Sandra E; Chopin, Michaël; Zhan, Yifan
Cellular & molecular immunology, 01/2023, Letnik: 20, Številka: 1Journal Article
The cytokine granulocyte-macrophage-colony stimulating factor (GM-CSF) possesses the capacity to differentiate monocytes into macrophages (MØs) with opposing functions, namely, proinflammatory M1-like MØs and immunosuppressive M2-like MØs. Despite the importance of these opposing biological outcomes, the intrinsic mechanism that regulates the functional polarization of MØs under GM-CSF signaling remains elusive. Here, we showed that GM-CSF-induced MØ polarization resulted in the expression of cytokine-inducible SH2-containing protein (CIS) and that CIS deficiency skewed the differentiation of monocytes toward immunosuppressive M2-like MØs. CIS deficiency resulted in hyperactivation of the JAK-STAT5 signaling pathway, consequently promoting downregulation of the transcription factor Interferon Regulatory Factor 8 (IRF8). Loss- and gain-of-function approaches highlighted IRF8 as a critical regulator of the M1-like polarization program. In vivo, CIS deficiency induced the differentiation of M2-like macrophages, which promoted strong Th2 immune responses characterized by the development of severe experimental asthma. Collectively, our results reveal a CIS-modulated mechanism that clarifies the opposing actions of GM-CSF in MØ differentiation and uncovers the role of GM-CSF in controlling allergic inflammation.
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in: SICRIS
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