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Pandey, Manish; Bansal, Sakshi; Chawla, Geetanjali
Experimental gerontology, 04/2022, Letnik: 160Journal Article
Evaluation of nutritionally enhanced biofortified dietary interventions that increase lifespan may uncover cost-effective and sustainable approaches for treatment of age-related morbidities and increasing healthy life expectancy. In this study, we report that anthocyanin rich, high yielding crossbred blue wheat prolongs lifespan of Drosophila melanogaster in different dietary contexts. In addition to functioning as an antioxidant rich intervention, the biofortified blue wheat also works through modulating expression of DR pathway genes including AMPK alpha, SREBP, PEPCK and Cry. Supplementation with blue- or purple-colored wheat provided better protection against paraquat-induced oxidative stress than control diet and increased survivability of flies in which superoxide dismutase 2 was knocked down conditionally in adults. Lastly, our findings indicate that supplementing biofortified blue wheat formulated diet prevented the decrease in lifespan and cardiac structural pathologies associated with intake of high fat diet. Overall, our findings indicate that plant-based diets formulated with biofortified cereal crops promote healthy ageing and delay progression of diseases that are exacerbated by accumulation of oxidative damage. •Biofortified wheat formulated diet prolongs Drosophila lifespan under ad libitum and dietary restriction.•Anthocyanin rich blue wheat formulated diet modulates expression of conserved effectors of dietary restriction pathway.•Anthocyanin rich blue wheat formulated diet enhances resistance to paraquat and hydrogen peroxide induced oxidative stress.•Biofortified blue wheat formulated diet prevents the adverse effects of high fat diet.
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