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Vázquez-Del Mercado, Mónica; Pérez-Vázquez, Felipe; Márquez-Aguirre, Ana L; Martínez-García, Erika-Aurora; Chavarria-Avila, Efrain; Ramos-Becerra, Carlos G; Aguilar-Vázquez, Andrea; Godínez-Rubí, Marisol; Martín-Márquez, Beatriz-Teresita; Gómez-Limón, Livier; Márquez-De-La-Paz, Guillermo; Rubio-Arellano, Edy-David; Pizano-Martinez, Oscar
Scientific reports, 11/2023, Letnik: 13, Številka: 1Journal Article
YKL-40 increase according to the aging process, and its functions have been associated with tissue remodeling and systemic inflammation. In Rheumatoid Arthritis (RA) it has been proposed as a possible biomarker of activity and severity, however; in the field of idiopathic inflammatory myopathies (IIM) the role of YKL-40 in IIM is not clear. Thus, we aimed to evaluate if there is an association between the serum levels and muscle tissue expression of YKL-40 with age, IIM phenotype, muscle strength and myositis disease activity. The main finding was that age is the most important variable that affects the YKL-40 serum levels. In muscle biopsy, we observed that YKL-40 is mainly expressed in infiltrating lymphoid cells than in muscle tissue. Using ANCOVA according to the b-coefficients, YKL-40 serum levels are predicted by inflammatory state, age, and IIM diagnosis.
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Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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