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Li, Shiling; Yu, Liqiong; Shi, Qian; Liu, Yue; Zhang, Yi; Wang, Shaohui; Lai, Xianrong
Biomedicine & pharmacotherapy, July 2022, 2022-Jul, 2022-07-00, 20220701, 2022-07-01, Letnik: 151Journal Article
Aconitine is a diterpenoid alkaloid, which mainly exists in the plants of Aconitum. In the last decade, a plethora of studies on the pharmacological activities of aconitine has been conducted and demonstrated that aconitine possessed an extensive range of pharmacological activities such as anti-tumor, anti-inflammatory, analgesic, local anesthesia, and immunomodulatory effects. Pharmacokinetic studies indicated that aconitine may have the characteristics of poor bioavailability, wide distribution, and slow elimination. However, studies have also found that aconitine has toxic effects on the heart, nerves, embryos, etc. Therefore, we believe that aconitine may not be suitable for heart patients and pregnant women to treat related diseases. It is important to note that all of these pharmacological effects require further high-quality studies to determine the clinical efficacy of aconitine. This review aims to summarize the advances in pharmacological, pharmacokinetics, toxicity, and detoxification of aconitine in the last decade with an emphasis on its anti-tumor and anti-inflammatory activities, to provide researchers with the latest information and point out the limitations of relevant research at the current stage and the aspects that should be strengthened in future research. Display omitted •Delineated pharmacokinetics, pharmacology and toxicity of aconitine.•Summarized the advances in anti-tumor mechanism of aconitine.•Discussed detoxification and some promising direction for further research on aconitine.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Vir: Osebne bibliografije
in: SICRIS
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