E-viri
Recenzirano
Odprti dostop
-
Wu, Sarah J.; Kim, Justin J.; Huang, Yeying; Durall, R. Taylor; Becker, Simone; Canty, Stephanie; Molinaro, Stefania; Pisick, Evan; Shapiro, Geoffrey I.; French, Christopher A.; Luo, Jia
JTO clinical and research reports, 01/2024, Letnik: 5, Številka: 1Journal Article
We present the first known case of a patient with BRD2::NUTM1-driven NUT carcinoma. A 59-year-old woman presented with poorly differentiated squamous cell lung cancer metastatic to the pleura. Eventually, a positive NUT immunohistochemistry, NUT fluorescence in situ hybridization, and RNA next-generation sequencing with a BRD2::NUTM1 fusion led to the diagnosis of NUT carcinoma. She received multiple lines of chemotherapy with response and is still alive at 2 years postdiagnosis. This report expands on the known fusions in NUT carcinoma and highlights potential differences in patient prognosis on the basis of gene fusion partners.
