In this article, we present the historical and current developments of inclusive education (IE) in the U.S. in the context of recent changes toward a more inclusive approach to education (IE) in the Czech Republic. We highlight the lessons learned with respect to the implementation of IE practices in U.S. schools as a means to uphold the right to education for all. Research findings of the impact of IE on the academic and social outcomes of children and youth with disabilities, from other diverse backgrounds and for students without disabilities are summarized. The goal of this article is to inspire educators and scholars in the Czech Republic and other countries in Central and Eastern Europe to utilize the presented information on IE research and implementation practices in their local educational contexts, taking into account both the local context and current needs.