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Hydbring, Per; Wang, Yinan; Bogorad, Roman L.; Yin, Hao; Anderson, Daniel G.; Li, Cheng; Sicinski, Piotr
Cell cycle (Georgetown, Tex.), 01/2017, Letnik: 16, Številka: 23Journal Article
By performing nine genome-wide microRNA (miRNA) screens, we recently uncovered a new class of miRNAs, which target multiple cyclins and cyclin-dependent kinases (CDKs). Systemic delivery of selected cell cycle-targeting miRNAs to mouse xenograft models resulted in potent anti-tumorigenic effects without affecting animals' health. Here, we provide an in-depth description of our miRNA screening methodology, analyses of selected cell cycle-targeting miRNAs, and discuss why miRNA therapy might be a viable therapeutic option for cancer patients.
