E-viri
Recenzirano
Odprti dostop
-
Gillespie, Anna K.; Jones, Emily A.; Lin, Yuan-Hung; Karlsson, Mattias P.; Kay, Kenneth; Yoon, Seo Yeon; Tong, Leslie M.; Nova, Philip; Carr, Jessie S.; Frank, Loren M.; Huang, Yadong
Neuron, 05/2016, Letnik: 90, Številka: 4Journal Article
Apolipoprotein (apo) E4 is the major genetic risk factor for Alzheimer’s disease (AD), but the mechanism by which it causes cognitive decline is unclear. In knockin (KI) mice, human apoE4 causes age-dependent learning and memory impairments and degeneration of GABAergic interneurons in the hippocampal dentate gyrus. Here we report two functional apoE4-KI phenotypes involving sharp-wave ripples (SWRs), hippocampal network events critical for memory processes. Aged apoE4-KI mice had fewer SWRs than apoE3-KI mice and significantly reduced slow gamma activity during SWRs. Elimination of apoE4 in GABAergic interneurons, which prevents learning and memory impairments, rescued SWR-associated slow gamma activity but not SWR abundance in aged mice. SWR abundance was reduced similarly in young and aged apoE4-KI mice; however, the full SWR-associated slow gamma deficit emerged only in aged apoE4-KI mice. These results suggest that progressive decline of interneuron-enabled slow gamma activity during SWRs critically contributes to apoE4-mediated learning and memory impairments. Display omitted •ApoE4-KI mice show age-dependent attenuation of slow gamma activity during SWRs•ApoE4-KI mice, both young and aged, have fewer SWRs than apoE3-KI mice•ApoE4-induced slow gamma impairment, not SWR abundance, is interneuron dependent•Progressive slow gamma dysfunction during SWRs may contribute to cognitive decline Gillespie et al. show that Alzheimer’s disease risk factor apoE4 alters hippocampal sharp-wave ripples (SWRs), network events important for memory function. In particular, dysfunction of SWR-associated slow gamma activity may critically contribute to apoE4-induced learning and memory impairment.
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.