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Sormani, Maria Pia; Cordioli, Cinzia; Comi, Giancarlo; Battaglia, Mario Alberto; Fragoso, Yara Dadalti; Sen, Sedat; Abbadessa, Gianmarco; Allegorico, Lia; Amato, Maria Pia; Annovazzi, Pietro; Appendino, Lucia; Barcella, Valeria; Baroncini, Damiano; Battaglia, Mario A.; Bergamaschi, Roberto; Bisecco, Alvino; Borriello, Giovanna; Bosco, Antonio; Brambilla, Laura; Bucello, Sebastiano; Cabboi, Maria Paola; Calabrese, Massimiliano; Calabria, Francesca; Camilli, Federico; Caniatti, Luisa Maria; Capra, Ruggero; Carmisciano, Luca; Carta, Patrizia; Cavalla, Paola; Celani, Maria Grazia; Cellerino, Maria; Chisari, Clara; Clerico, Marinella; Conte, Antonella; Cordano, Christian; Cordera, Susanna; Cordioli, Cinzia; Corea, Francesco; Curti, Erica; D’Amico, Emanuele; De Luca, Giovanna; De Mercanti, Stefania Federica; De Rossi, Nicola; di Napoli, Mario; Docimo, Renato; Dutto, Anna; Evangelista, Luana; Ferrò, Maria Teresa; Govone, Flora; Granella, Franco; Guidetti, Donata; Iasevoli, Luigi; Infante, Maria Teresa; Leva, Serena; Longoni, Marco; Lopiano, Leonardo; Lucchini, Matteo; Malucchi, Simona; Marangoni, Sabrina; Martinelli Boneschi, Filippo; Mendozzi, Laura; Miante, Silvia; Milano, Eva; Mirabella, Massimiliano; Moiola, Lucia; Montini, Federico; Motta, Roberta; Onofrj, Marco; Pasquali, Livia; Patti, Francesco; Pedrazzoli, Elisabetta; Pesci, Ilaria; Petrone, Alfredo; Pietroboni, Anna M.; Pinardi, Federica; Ponzano, Marta; Pozzato, Mattia; Pozzilli, Carlo; Prosperini, Luca; Protti, Alessandra; Radaelli, Marta; Repice, Anna; Rigoni, Eleonora; Romano, Calogero Marcello; Ronzoni, Marco; Salvetti, Marco; Schillaci, Valentina; Sgarito, Caterina; Siciliano, Gabriele; Signoriello, Elisabetta; Sinisi, Leonardo; Sparaco, Maddalena; Susani, Laura Emanuela; Tabiadon, Giulietta; Teatini, Francesco; Vianello, Marika; Virgilio, Eleonora; Vitetta, Francesca; Vollaro, Stefano; Zito, Antonio
Multiple sclerosis, 06/2022, Letnik: 28, Številka: 7Journal Article
Background: The MuSC-19 project is an Italian cohort study open to international partners that collects data on multiple sclerosis (MS) patients with COVID-19. During the second wave of the pandemic, serological tests became routinely available. Objective: To evaluate the seroprevalence of anti-SARS-CoV-2 antibodies according to the use of disease-modifying therapy (DMT) in a subset of patients included in the MuSC-19 data set who had undergone a serological test. Methods: We evaluated the association between positive serological test results and time elapsed since infection onset, age, sex, Expanded Disability Status Scale score, comorbidities and DMT exposure using a multivariable logistic model. Results: Data were collected from 423 patients (345 from Italy, 61 from Turkey and 17 from Brazil) with a serological test performed during follow-up. Overall, 325 out of 423 tested patients (76.8%) had a positive serological test. At multivariate analysis, therapy with anti-CD20 was significantly associated with a reduced probability of developing antibodies after COVID-19 (odds ratio (OR) = 0.20, p = 0.002). Conclusion: Patients with MS maintain the capacity to develop humoral immune response against SARS-COV-2, although to a lesser extent when treated with anti-CD20 drugs. Overall, our results are reassuring with respect to the possibility to achieve sufficient immunization with vaccination.
