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Gupta, Shobhit; Stamatoyannopoulos, John A; Bailey, Timothy L; Noble, William Stafford
Genome biology, 01/2007, Letnik: 8, Številka: 2Journal Article
A common question within the context of de novo motif discovery is whether a newly discovered, putative motif resembles any previously discovered motif in an existing database. To answer this question, we define a statistical measure of motif-motif similarity, and we describe an algorithm, called Tomtom, for searching a database of motifs with a given query motif. Experimental simulations demonstrate the accuracy of Tomtom's E values and its effectiveness in finding similar motifs.
