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Wang, Ju; Casimiro-Garcia, Agustin; Johnson, Bryce G; Duffen, Jennifer; Cain, Michael; Savary, Leigh; Wang, Stephen; Nambiar, Prashant; Lech, Matthew; Zhao, Shanrong; Xi, Li; Zhan, Yutian; Olson, Jennifer; Stejskal, James A; Lin, Hank; Zhang, Baohong; Martinez, Robert V; Masek-Hammerman, Katherine; Schlerman, Franklin J; Dower, Ken
Scientific reports, 10/2023, Letnik: 13, Številka: 1Journal Article
Type 2 diabetes (T2D) and its complications can have debilitating, sometimes fatal consequences for afflicted individuals. The disease can be difficult to control, and therapeutic strategies to prevent T2D-induced tissue and organ damage are needed. Here we describe the results of administering a potent and selective inhibitor of Protein Kinase C (PKC) family members PKCα and PKCβ, Cmpd 1, in the ZSF1 obese rat model of hyperphagia-induced, obesity-driven T2D. Although our initial intent was to evaluate the effect of PKCα/β inhibition on renal damage in this model setting, Cmpd 1 unexpectedly caused a marked reduction in the hyperphagic response of ZSF1 obese animals. This halted renal function decline but did so indirectly and indistinguishably from a pair feeding comparator group. However, above and beyond this food intake effect, Cmpd 1 lowered overall animal body weights, reduced liver vacuolation, and reduced inguinal adipose tissue (iWAT) mass, inflammation, and adipocyte size. Taken together, Cmpd 1 had strong effects on multiple disease parameters in this obesity-driven rodent model of T2D. Further evaluation for potential translation of PKCα/β inhibition to T2D and obesity in humans is warranted.
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