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Shin, E-J; Kim, J-M; Nguyen, X-K T; Nguyen, T-T L; Lee, S Y; Jung, J-H; Kim, M J; Whang, W K; Yamada, K; Nabeshima, T; Kim, H-C
Current neuropharmacology, 03/2011, Letnik: 9, Številka: 1Journal Article
It has been demonstrated that 5-HT1A receptors play an important role in the pathophysiology of schizophrenia. Because Gastrodia elata Bl (GE) modulates the serotonergic system, we examined whether GE could affect phencyclidine (PCP)-induced abnormal behavior in mice. Repeated treatment with PCP increased immobility time, while it decreased social interaction time and recognition memory. PCP-induced abnormal behaviors were significantly attenuated by GE, and these effects were comparable to those of 8-OH-DPAT, a 5-HT1A receptor agonist. Furthermore, GE-mediated effects were counteracted by WAY 100635, a 5-HT1A receptor antagonist. Our results suggest that the antipsychotic effects of GE are, at least in part, mediated via activation of 5-HT1A in mice.
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in: SICRIS
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