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Mularoni, Valentina; Donati, Benedetta; Tameni, Annalisa; Manicardi, Veronica; Reggiani, Francesca; Sauta, Elisabetta; Zanelli, Magda; Tigano, Marco; Vitale, Emanuele; Torricelli, Federica; Ascani, Stefano; Martino, Giovanni; Inghirami, Giorgio; Sanguedolce, Francesca; Ruffini, Alessia; Bavieri, Alberto; Luminari, Stefano; Pizzi, Marco; Dei Tos, Angelo Paolo; Fesce, Cinzia; Neri, Antonino; Ciarrocchi, Alessia; Fragliasso, Valentina
Haematologica, 12/2023, Letnik: 108, Številka: 12Journal Article
Long non-coding RNA (lncRNA) are emerging as powerful and versatile regulators of transcriptional programs and distinctive biomarkers of progression of T-cell lymphoma. Their role in the aggressive anaplastic lymphoma kinase-negative (ALK-) subtype of anaplastic large cell lymphoma (ALCL) has been elucidated only in part. Starting from our previously identified ALCL-associated lncRNA signature and performing digital gene expression profiling of a retrospective cohort of ALCL, we defined an 11 lncRNA signature able to discriminate among ALCL subtypes. We selected a not previously characterized lncRNA, MTAAT, with preferential expression in ALK- ALCL, for molecular and functional studies. We demonstrated that lncRNA MTAAT contributes to an aberrant mitochondrial turnover restraining mitophagy and promoting cellular proliferation. Functionally, lncRNA MTAAT acts as a repressor of a set of genes related to mitochondrial quality control via chromatin reorganization. Collectively, our work demonstrates the transcriptional role of lncRNA MTAAT in orchestrating a complex transcriptional program sustaining the progression of ALK- ALCL.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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