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Hodnik, Žiga; Łoś, Joanna M.; Žula, Aleš; Zidar, Nace; Jakopin, Žiga; Łoś, Marcin; Sollner Dolenc, Marija; Ilaš, Janez; Węgrzyn, Grzegorz; Peterlin Mašič, Lucija; Kikelj, Danijel
Bioorganic & medicinal chemistry letters, 06/2014, Letnik: 24, Številka: 11Journal Article
Herein, we describe indole-based analogues of oroidin as a novel class of 2-aminoimidazole-based inhibitors of methicillin-resistant Staphylococcus aureus biofilm formation and, to the best of our knowledge, the first reported 2-aminoimidazole-based inhibitors of Streptococcus mutans biofilm formation. This study highlighted the indole moiety as a dibromopyrrole mimetic for obtaining inhibitors of S. aureus and S. mutans biofilm formation. The most potent compound in the series, 5-(trifluoromethoxy)indole-based analogue 4b (MBIC50=20μM), emerged as a promising hit for further optimisation of novel inhibitors of S. aureus and S. mutans biofilms.
