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Thomson, Peter C.; Mark, Patrick B.; Robertson, Michele; White, Claire; Anker, Stefan D.; Bhandari, Sunil; Farrington, Kenneth; Jardine, Alan G.; Kalra, Philip A.; McMurray, John; Reddan, Donal; Wheeler, David C.; Winearls, Christopher G.; Ford, Ian; Macdougall, Iain C.; Winnett, Georgia; Akbani, Habib; Winearls, Christopher; Wessels, Julie; Ayub, Waqar; Connor, Andrew; Brown, Alison; Chowdury, Paramit; Griffiths, Megan; Dasgupta, Indranil; Bhandari, Sunil; Doulton, Timothy; Macdougall, Iain; Barratt, Jonathan; Vilar, Enric; Mitra, Sandip; Ramakrishna, Babu; Nicholas, Johann; Khwaja, Arif; Hall, Matt; Kirk, Adam; Smith, Stuart; Jesky, Mark; Day, Clara; Alchi, Bassam; Stratton, Jon; Clarke, Helen; Walsh, Stephen; Brown, Rebecca; McCafferty, Kieran; Solomon, Laurie; Ramadoss, Suresh; Lawman, Sarah; Kalra, Philip; Balasubramaniam, Gowrie; Power, Albert; Banerjee, Debasish; Swift, Pauline; Wellberry-Smith, Matt; Goldsmith, Christopher; Ledson, Thomas; Mikhail, Ashraf; Benzimra, Ruth; Bell, Samira; Severn, Alison; Neary, John; Doyle, Arthur; Thomson, Peter; Shivashankar, Girish; Bolton, Stephanie; Quinn, Michael; Maxwell, Peter; Macdougall, Iain; Ford, Ian; Anker, Stefan; Farrington, Kenneth; McMurray, John; Tomson, Charles; Wheeler, David; McMurray, John; Petrie, Mark; Connolly, Eugene; Jhund, Pardeep; MacDonald, Michael; Mark, Patrick; Walters, Matthew; Peacock, Janet; Isles, Chris; Reddan, Donal; Ford, Ian; Aziz, Jane; Boyle, Sarah; Burton, Claire; Clarke, Ross; Dinnett, Eleanor; Hillen, Neil; Kean, Sharon; Kerr, Claire; Murray, Heather; Reid, Amanda; Wetherall, Kirsty; Wilson, Robbie; Macdougall, Iain; White, Claire; Andani, Sadiq
Kidney international reports, 08/2022, Letnik: 7, Številka: 8Journal Article
Treatment of anemia in dialysis patients has been associated with increased risk of vascular access thrombosis (VAT). Proactive IV irOn Therapy in hemodiALysis Patients (PIVOTAL) was a clinical trial of proactive compared with reactive i.v. iron therapy in patients requiring hemodialysis. We analyzed the trial data to determine whether randomized treatment arm, alongside other clinical and laboratory variables, independently associated with VAT. In PIVOTAL, 2141 adult patients were randomized. The type of vascular access (arteriovenous fistula AVF, arteriovenous graft AVG, or central venous catheter CVC) was recorded at baseline and every month after randomization. The associations between clinical and laboratory data and first VAT were evaluated in a multivariate analysis. A total of 480 (22.4%) participants experienced VAT in a median of 2.1 years of follow-up. In multivariable analyses, treatment arm (proactive vs. reactive) was not an independent predictor of VAT (hazard ratio HR 1.13, P = 0.18). Diabetic kidney disease (HR 1.45, P < 0.001), AVG use (HR 2.29, P < 0.001), digoxin use (HR 2.48, P < 0.001), diuretic use (HR 1.25, P = 0.02), female sex (HR 1.33, P = 0.002), and previous/current smoker (HR 1.47, P = 0.004) were independently associated with a higher risk of VAT. Angiotensin receptor blocker (ARB) use (HR 0.66, P = 0.01) was independently associated with a lower risk of VAT. In PIVOTAL, VAT occurred in nearly 1 quarter of participants in a median of just >2 years. In this post hoc analysis, randomization to proactive i.v. iron treatment arms did not increase the risk of VAT. Display omitted
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Vir: Osebne bibliografije
in: SICRIS
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