•SBS modifiers enhanced low-temperature crack resistance of asphalt binder.•High strain fatigue life of the SBS modified mastic asphalt mixtures was improved.•The SBS modified mixtures had greater flexural toughness than control mixtures.•The SBS modifiers was more substantial in retarding fatigue crack growth. This study evaluated the fatigue performance of Styrene–Butadiene–Styrene (SBS) modified mastic asphalt mixtures used for bridge deck pavements. The effect of the type and content of newly developed SBS modifiers was investigated using typical binder tests. Four-point bending beam fatigue and indirect strength tests were conducted to examine fatigue and fracture behaviors of the SBS modified mastic asphalt mixtures. The SBS modifiers without CC double bonds enhanced the mechanical properties of the mastic asphalt binder and mixtures: lower stiffness after short- and long-term oxidation, significantly greater fatigue resistance at a higher strain level, and higher crack development resistance.