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Taylor, Craig J.; Peacock, Sarah; Chaudhry, Afzal N.; Bradley, J. Andrew; Bolton, Eleanor M.
Cell stem cell, 08/2012, Letnik: 11, Številka: 2Journal Article
The likelihood for immunological rejection of Human Leukocyte Antigens (HLA)-mismatched induced pluripotent stem cells (iPSCs) limits their therapeutic potential. Here we show how a tissue bank from 150 selected homozygous HLA-typed volunteers could match 93% of the UK population with a minimal requirement for immunosuppression. Our model provides a practical approach for using existing HLA-typed samples to generate an iPSC stem cell bank that circumvents prospective typing of a large number of individuals.
