Cockcroft-Gault Versus Modification of Diet in Renal Disease: Importance of Glomerular Filtration Rate Formula for Classification of Chronic Kidney Disease in Patients With Non–ST-Segment Elevation Acute Coronary Syndromes Chiara Melloni, Eric D. Peterson, Anita Y. Chen, Lynda A. Szczech, L. Kristin Newby, Robert A. Harrington, W. Brian Gibler, E. Magnus Ohman, Sarah A. Spinler, Matthew T. Roe, Karen P. Alexander We calculated estimated glomerular filtration rate (GFR) by Cockcroft-Gault (C-G) and Modification of Diet in Renal Disease formulae in 46,942 non–ST-segment elevation acute coronary syndromes patients from 408 CRUSADE (Can Rapid risk stratification of Unstable angina patients Suppress ADverse outcomes with Early implementation of the American College of Cardiology/American Heart Association Guidelines) hospitals. The C-G formula provides a more conservative estimate of GFR, particularly in high-risk subgroups. More patients require dose adjustments based on C-G, and those adjusted by C-G bleed less. Dosing based on the C-G formula is preferable, particularly in the small, female, or elderly patient.