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Nguyen, Thi Hue Hanh; Lu, Y-Thanh; Le, Van Hoi; Bui, Vinh Quang; Nguyen, Lan Hieu; Pham, Nhu Hiep; Phan, Thanh Hai; Nguyen, Huu Thinh; Tran, Van Song; Bui, Chi Viet; Vo, Van Kha; Nguyen, Pham Thanh Nhan; Dang, Ha Huu Phuoc; Pham, Van Dung; Cao, Van Thinh; Nguyen, Thanh Dat; Nguyen, Luu Hong Dang; Phan, Ngoc Minh; Nguyen, Trong Hieu; Nguyen, Van Thien Chi; Pham, Thi Mong Quynh; Tran, Vu Uyen; Le, Minh Phong; Vo, Dac Ho; Tran, Thi Minh Thu; Nguyen, Minh Nguyen; Nguyen, Thi Thanh; Tieu, Ba Linh; Nguyen, Huu Tam Phuc; Truong, Dinh Yen An; Cao, Chi Thuy Tien; Nguyen, Van Tung; Le, Thi Le Quyen; Luong, Thi Lan Anh; Doan, Thi Kim Phuong; Dao, Thi Trang; Phan, Canh Duy; Nguyen, Thanh Xuan; Pham, Nguyen Tuong; Nguyen, Bao Toan; Pham, Thi Thu Thuy; Le, Huu Linh; Truong, Cong Thanh; Jasmine, Thanh Xuan; Le, Minh Chi; Phan, Van Bau; Truong, Quang Binh; Tran, Thi Huong Ly; Huynh, Minh Thien; Tran, Tu Quy; Nguyen, Si Tuan; Tran, Vu; Tran, Van Khanh; Nguyen, Huu Nguyen; Nguyen, Duy Sinh; Nguyen, Thi Quynh Tho; Phan, Thi Van; Do, Thi Thanh-Thuy; Truong, Dinh-Kiet; Tang, Hung Sang; Phan, Minh Duy; Giang, Hoa; Nguyen, Hoai Nghia; Tran, Le Son
Cancer investigation, 03/2023, Letnik: 41, Številka: 3Journal Article
The SPOT-MAS assay "Screening for the Presence Of Tumor by Methylation And Size" detects the five most common cancers in Vietnam by evaluating circulating tumor DNA in the blood. Here, we validated its performance in a prospective multi-center clinical trial, K-DETEK. Our analysis of 2795 participants from 14 sites across Vietnam demonstrates its ability to detect cancers in asymptomatic individuals with a positive predictive value of 60%, with 83.3% accuracy in detecting tumor location. We present a case report to support further using SPOT-MAS as a complementary method to achieve early cancer detection and provide the opportunity for early treatment.
