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Kortum, Robert L.; Morrison, Deborah K.
Cancer cell, 09/2015, Letnik: 28, Številka: 3Journal Article
Current BRAF inhibitors block signaling from monomeric BRAFV600E, but not from oncogenic RAS, which requires RAF dimerization. In this issue of Cancer Cell, Yao and colleagues investigate why current drugs are ineffective against RAF dimers, while Peng and colleagues describe a pan-RAF inhibitor targeting both monomeric and dimeric RAF. Current BRAF inhibitors block signaling from monomeric BRAFV600E, but not from oncogenic RAS, which requires RAF dimerization. In this issue of Cancer Cell, Yao and colleagues elucidate why current drugs are ineffective against RAF dimers, while Peng and colleagues describe a pan-RAF inhibitor targeting both monomeric and dimeric RAF.
