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Shah, Sanjiv J., MD
Journal of the American College of Cardiology, 10/2013, Letnik: 62, Številka: 15Journal Article
Ivabradine is a highly selective blocker of inward "funny" channels, which are central regulators of spontaneous depolarization in pacemaker cells (19). ...ivabradine selectively decreases heart rate without having negative inotropic or lusitropic effects, as can occur with beta-blockers. ...the primary endpoints for a large-scale clinical trial of ivabradine in HFpEF should be exercise capacity and quality of life, with prevention of worsening HF (i.e., HF hospitalization) as a secondary, exploratory endpoint.
