E-viri
Recenzirano
Odprti dostop
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Strober, Bruce, MD, PhD; Leonardi, Craig, MD; Papp, Kim A., MD, PhD, FRCPC; Mrowietz, Ulrich, MD; Ohtsuki, Mamitaro, MD, PhD; Bissonnette, Robert, MD, MSc, FRCPC; Ferris, Laura K., MD, PhD; Paul, Carle, MD, PhD; Lebwohl, Mark, MD, FAAD; Braun, Daniel K., MD, PhD; Mallbris, Lotus, MD, PhD; Wilhelm, Stefan, MD; Xu, Wen, PhD; Ljungberg, Anders, MD; Acharya, Nayan, MBBS, MRCP, MFPM; Reich, Kristian, MD, PhD
Journal of the American Academy of Dermatology, 03/2017, Letnik: 76, Številka: 3Journal Article
Background Safety of biologics is important when treating patients with psoriasis. Objective We sought to determine the safety of ixekizumab in psoriasis. Methods Integrated safety data are presented from a 12-week induction period, a 12- to 60-week maintenance period, and from all ixekizumab-treated patients from 7 clinical trials. Exposure-adjusted incidence rates (IRs) per 100 patient-years are reported. Results Overall, 4209 patients received ixekizumab (total exposure: 6480 patient-years). During the induction period, the IRs of patients experiencing 1 or more treatment-emergent adverse event (AE) were 251 and 236 among ixekizumab- and etanercept-treated patients, respectively, and for serious AEs was 8.3 in both groups. During maintenance, for ixekizumab, the IRs of treatment-emergent AEs and serious AEs were 100.4 and 7.8, respectively. Among all ixekizumab-treated patients from 7 trials, the IR of Candida infections was 2.5. The IRs of treatment-emergent AEs of special interest (including serious infections, malignancies, major adverse cardiovascular events) were comparable for ixekizumab and etanercept during the induction period. Limitations Additional long-term data are required. Conclusion Ixekizumab had an acceptable safety profile with no unexpected safety findings during ixekizumab maintenance in psoriasis.
Avtor
Vnos na polico
Trajna povezava
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Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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