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McAllister, Jan M; Legro, Richard S; Modi, Bhavi P; Strauss, Jerome F
Trends in endocrinology and metabolism, 03/2015, Letnik: 26, Številka: 3Journal Article
Highlights • GWAS have identified FHSR, LHCGR, INSR , and DENND1A as PCOS candidate genes. • Overexpression of DENND1A variant 2 increases androgen biosynthesis in theca cells from normal cycling women, converting them to a PCOS phenotype. • DENND1A, LHCGR, INSR , and RAB5B form a hierarchal signaling network that can influence androgen synthesis. • DENND1A variant 2 is a new diagnostic and therapeutic target for PCOS.
