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Ruz-Caracuel, Ignacio; Ramón-Patino, Jorge L; López-Janeiro, Álvaro; Yébenes, Laura; Berjón, Alberto; Hernández, Alicia; Gallego, Alejandro; Heredia-Soto, Victoria; Mendiola, Marta; Redondo, Andrés; Peláez-García, Alberto; Hardisson, David
Cancers, 11/2019, Letnik: 11, Številka: 12Journal Article
Low-grade and early Federation for Gynecology and Obstetrics (FIGO) stage endometrioid endometrial carcinomas (EEC) have an excellent prognosis. However, approximately 10% of patients develop recurrence, which cannot be correctly predicted at diagnosis. We evaluated myoinvasive patterns as a prognostic factor of relapse in low-grade, early-stage EEC. Two-hundred and fifty-eight cases were selected according to the following inclusion criteria: (i) endometrioid endometrial carcinomas, (ii) grade 1 or 2 with (iii) FIGO stage I or II, and (iv) clinical follow-up. Slides were reviewed to annotate the myoinvasive pattern present in each case (infiltrative glands, microcystic, elongated and fragmented -MELF-, broad front, adenomyosis-like and adenoma malignum). Microsatellite instability was studied by immunoexpression of mismatch repair proteins (MLH1, PMS2, MSH2, and MSH6). There were 29 recurrences (11.2%) among the 258 cases analysed. A predominant broad front myoinvasive pattern was significantly associated with tumour relapse ( = 0.003). The presence of a pattern of infiltrative glands ( = 0.001) and microsatellite instability ( = 0.004) were associated with lower disease-free survival, without having an impact on overall survival. Our observations suggest the potential value of the pattern of myoinvasion as a prognostic factor in low-grade, early-stage endometrioid endometrial carcinoma.
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in: SICRIS
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