Abstract Purpose of the study To assess the effects of receiving a research informational pamphlet produced by the federal Office for Human Research Protections on telephone survey participation rates of older Latinos, and illustrate the feasibility of nesting recruitment studies within other funded studies when stand alone funding for recruitment studies is limited. Design and methods Latino patients aged ≥ 50 with ≥ 1 visit during the preceding year (N = 1314) were sampled from three community clinics and a multi-specialty medical group. Patients were randomly assigned to receive or not receive a pamphlet that contained information on research participation in the initial mailing for the telephone survey study. Survey participation rates were compared between the pamphlet and no pamphlet groups. Results In a multivariate model, women (OR = 1.4; 95% CI 1.1, 1.8), and those with public insurance (vs. no insurance; OR = 1.7; 95% CI 1.1, 2.5) were more likely to participate, while those age 65 + (vs. age 50–54; OR = 0.6; 95% CI 0.4, 0.8) were less likely to participate; there was no significant difference by pamphlet group (OR = 0.8; 95% CI 0.7, 1.1). Nesting of the randomized trial of the recruitment pamphlet within the funded study required minimal additional resources. Implications Recruitment methods that are more intensive than a pamphlet may be needed to enhance survey participation rates among older Latinos. Nesting recruitment trials within funded studies is a promising and efficient approach for testing recruitment strategies.